报告人：Prof. Hao Cheng （成昊） Department of Materials Science and Engineering, Drexel University, Philadelphia, USA.
I will report our research on ultra-long circulating nanoparticles and their application in cancer therapy. We have found that a hierarchical polyethylene glycol (PEG) shell is highly efficient in prolonging nanoparticle blood circulation times through a dynamic effect. High density PEG shell in the brush regime does not have this effect. In this talk, I will show how the dynamic effect affects protein adsorption on nanoparticles and nanoparticle interaction with liver cells. Based on this design, we have developed a unique enzyme conjugation strategy that embeds enzymes in hierarchical PEG shell instead of exposing enzymes to the outmost surface of nanoparticles. This strategy dramatically increased nanoparticle diffusion and accumulation in solid tumors via extended nanoparticle blood circulation time and tumor matrix degradation, leading to a highly efficient antitumor efficacy. The technology of controlling topographical structure of nanocarriers may be valuable to enhance the clinical efficacy of many drug nanocarriers.
Dr. Hao Cheng is an Assistant Professor in the Department of Materials Science & Engineering at Drexel University, and affiliated faculty member in the School of Biomedical Engineering, Science, and Health Systems. He received his B.E. and M.S. degrees in Chemical Engineering from Tsinghua University in 1999 and 2001, respectively, and his Ph.D. degree in Materials Science & Engineering from Northwestern University in 2005. He was a postdoctoral associate in cancer biology at Northwestern University, and Koch Institute for Integrative Cancer Research and Department of Chemical Engineering at MIT from 2006 to 2012. He has published 30 papers in Journals such as PNAS, Nano Letters, ACS Nano, and Advanced Materials. His current research focuses on the investigation of fundamental nanomaterial-cell interactions and the development of new biomaterials for immunotherapy.