陈峰

博士、讲席教授


北京大学工学院副院长
北京大学终身讲席教授
北京大学食品与生物资源工程研究所所长
新加坡-北京大学低碳研究中心主任
国家 “千人计划” 获得者
长江学者特聘教授


联系电话:010-62745356
电子邮箱:sfchencoe@pku.edu.cn
个人主页:http://www2.coe.pku.edu.cn/subpaget.asp?id=406


陈峰

教育经历:

1993年7月 澳大利亚 昆士兰大学 博士
1990年12月 澳大利亚 昆士兰大学 硕士
1983年7月 华南工学院(现华南理工大学) 学士

 

研究领域:

微藻生物工程(包括微藻生物能源)
生物资源工程
功能食品
生化工程

 

背景资料:

现任北京大学工学院副院长、终身讲席教授、中国食品科技学会功能食品分会常务副理事长兼秘书长,兼任北京大学工学院食品与生物资源工程研究所所长、新加坡-北京大学低碳研究中心主任。国家“千人计划”获得者, 曾入选教育部“长江学者”和中科院 “百人计划”。陈峰1993年毕业于澳大利亚昆士兰大学化学工程系,获生化工程博士学位, 澳大利亚注册工程师。曾任香港大学终身教授兼任植物学系系主任及生物科学学院执行院长。陈峰的研究工作主要集中在微藻生物工程(包括微藻生物能源)、功能食品、生化工程及生物资源工程等领域。率先提出利用异养方式规模化高密度培养微藻以生产高附加值功能性食品成分及藻类生物能源(例如,脂质),他同时将研究扩展到其它微生物和植物资源的开发及功能性成分研究等领域。迄今已在国际权威学术期刊(SCI)发表250余篇研究论文和综述(SCI引用愈7000次,H-index 44)、专箸4本、美国及中国专利共6项。多次在国际学术会议作大会特邀发言, 多次组织国际学术会议。 被Essential Science Indicators评为“Highly Cited Scientist” (top 1%)。 陈峰还兼任英国皇家化学会期刊Food & Function副主编和另外4个国际学术期刊编委(Process Biochemistry, Journal of Applied Phycology, Biotechnology Letters, Journal of Agricultural and Food Chemistry)。

 

获得荣誉:

曾获香港大学“杰出青年研究奖”、“杰出研究生导师奖”、“法国-香港联合研究奖”、“首届中国食品科技杰出中青年奖”,2008年被选为“美国医学和生物工程院(AIMBE)院士”,2010年获“美国化学工程师学会大会奖”,2011年被选为“英国皇家化学会会士”,2014年被选为“国际食品科学院院士”,2014年被选为“国际欧亚科学院院士”。

 

部分著作及论文:


I. Book
1. Chen, F. & Jiang, Y. (eds) (1999). Microalgal Biotechnology. China Light Industry Press, Beijing, 348 pp.
2. Chen, F. & Jiang Y. (eds) (2001). Algae and their Biotechnological Potential. Kluwer Academic Publishers, Dordrecht, the Netherlands, 316 pp.
3. Chen, F. & Whitton, B. A. (eds) (2001). Special Issue of Journal of Applied Phycology, Vol. 3, No. 4., Kluwer Academic Publishers, Dordrecht, the Netherlands, 110 pp.
4. Chen, F., Li, J.R., Hu, X.S., Liu, X., Meng S.H. & Shao, W. (2002). Modern Biological & Food Technology. China Light Industry Press, Beijing, 304 pp.
 
II. Patents
Six patents in total (including Chinese patents and U.S. patents, etc.).


III. Full SCI Journal Publication List
KEY: * = Corresponding Author (Senior Author).
Total citations: >6300; H-index: 43
250. Liu, J., Zheng, S., Gerken, H., Huang, J.C., Jiang, Y., Chen, F.* (2014). Genetic engineering of the green alga Chlorella zofingiensis: a modified norflurazon-resistant phytoene desaturase gene as a dominant selectable marker. Applied Microbiology and Biotechnology (in press).
249. Zhang, X.C., Chen, F. & Wang, M.F. (2014). Antioxidant and anti-glycation activity of selected dietary polyphenols in cookie model. Journal of Agricultural and Food Chemistry, 62, 1643-1648.
248. Zhang, J., Sun, Z., Sun, P.P., Chen, T.P. & Chen, F.* (2014). Microalgal carotenoids: beneficial effects and potential in human health. Food & Function, 5, 413-425.
247. Liu, J., Gerken, H., Huang, J.C. & Chen, F.* (2013). Engieering of an endogenous phytoene desaturase gene as a dominant selectable marker for Chlamydomonas reinhardtii transformation and enhanced biosynthesis of carotenoids. Process Biochemistry, 48, 788-795.
246. Huangfu, J.Q., Liu, J., Sun, Z., Wang, M.F., Jiang, Y., Chen, Z.Y. & Chen, F.* (2013). Anti-ageing effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress. Journal of Agricultural and Food Chemistry, 61, 7800-7804.
245. Zhang, X.C., Chen, F. & Wang, M.F. (2013). Impacts of selected dietary polyphenols on caramelization in model systems. Food Chemistry, 141, 3451-3458.
244. Huang, J.C., Zhong, Y.J., Sandmann, G., Liu, J. & Chen, F.* (2013). Metabolic engineering of tomato for high-yield production of astaxanthin. Metabolic Engineering, 17, 59-67.
243. Lu, N., Wei, D., Chen, F. & Yang, S.T. (2013). Lipidomic profiling reveals lipid regulation in the snow alga Chlamydomonas nivalis in response to nitrate or phosphate deprivation. Process Biochemistry, 48, 605-613.
242. Liu, J., Sun, Z., Zhong, Y.J., Gerken, H., Huang, J.C. & Chen, F.* (2013). Utilization of cane molasses towards cost-saving astaxanthin production by a Chlorella zofingiensis mutant. Journal of Applied Phycology, 25, 1447-1456.
241. Huangfu, J.Q., Liu, J., Peng, C., Suen, Y.L., Wang, M.F., Chen, Z.Y. & Chen, F.* (2013). DHA-rich marine microalga Schizochytrium mangrovei possesses antiageing effects on Drosophila melanogaster. Journal of Functional Foods, 5, 888-896.
240. Li, F., Li, S., Li, H.B., Deng, G.F., Ling, W.H., Wu, S., Xu, X.R. & Chen, F. (2013). Antiproliferative activity of peels, pulps and seeds of 61 fruits. Journal of Functional Foods, 5, 1298-1309.
239. Song, Y., Deng, G.F., Xu, X.R., Chen, Y.H., Chen, F. & Li, H.B. (2013). Nitrate and nitrite content in bottled beverages by ion-pair high-performance liquid chromatography. Food Additives & Contaminants Part B Surveillance, 6, 42-46.
238. Zhu, Q., Qian, Y.S., Zheng, Z.P., Lo, C., Chen, F. & Wang, M.F. (2013). Natural polyphenols alleviated lipid peroxidation-induced modification on BSA. Journal of Functional Foods, 5, 355-361.
237. Liu, J., Sun, Z., Zhong, Y.J., Huang, J.C., Hu, Q. & Chen, F.* (2012). Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis.  Planta, 236, 1665-1676.
236. Deng, G.F., Shen, C., Xu, X.R., Kuang, R.D., Guo, Y.J., Zeng, L.S., Gao, L.L., Lin, X., Xie, J.F., Xia, E.Q., Li, S., Wu, S., Chen, F., Ling, W.H. & Li, H.B. (2012). Potential of fruit wastes as natural resources of bioactive compounds.  International Journal of Molecular Sciences, 13, 8308-8323.
235. Deng, G.F., Xu, X.R., Guo, Y.J., Xia, E.Q., Li, S., Wu, S., Chen, F., Ling, W.H., & Li, H.B. (2012). Determination of antioxidant property and their lipophilic and hydrophilic phenolic contents of in cereal grains. Journal of Functional Foods, 4, 906-914.
234. Guo, Y.J., Deng, G.F., Xu, X.R., Wu, S., Li, S., Xia, E.Q., Li, F., Chen, F., Ling, W.H. & Li, H.B. (2012). Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food & Function, 3, 1195-1205.
233. Lu, N., Wei, D., Jiang, X.L. & Chen, F. (2012). Fatty acids profiling and biomarker identification in snow alga Chlamydomonas nivalis by NaCl stress using GC/MS and multivariate statistical analysis. Analytical Letters, 45, 1172-1183.
232. Zhu, Q., Zhang, N.Q., Lau, C.F., Chao, J.F., Sun, Z., Chang, R.C.C., Chen, F. & Wang, M.F. (2012). In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple. Food Chemistry, 135, 1762-1768.
231. Lu, N., Wei, D., Jiang, X.L., Chen, F. & Yang, S.T. (2012). Regulation of lipid metabolism in the snow alga Chlamydomonas nivalis in response to NaCl stress: an integrated analysis by cytomic and lipidomic approaches. Process Biochemistry, 47, 1163-1170.
230. Huang, J.C., Zhong, Y.J., Sandmann, G. , Liu, J. & Chen, F.* (2012). Cloning and selection of carotenoid ketolase genes for the engineering of high-yield astaxanthin in plants. Planta, 236, 691-699.
229. Sun, Z., Chen, J.N., Ma, J.Y., Jiang, Y., Wang, M.F. & Ren, G.X. & Chen, F.* (2012). Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. Journal of Agricultural and Food Chemistry, 60, 3260-3265.
228. Sun, Z. & Chen, F.* (2012). Evaluation of the green alga Chlorella pyrenoidosa for management of diabetes. Journal of Food and Drug Analysis, 20 (suppl. 1), 246-249.
227. Lu, N., Wei, D., Chen, F. & Yang, S.T. (2012).  Lipidomic profiling and discovery of lipid biomarkers in snow alga Chlamydomonas nivalis by salt stress. European Journal of Lipid Science and Technology, 114, 253-265.
226. Liu, J. Huang, J.C., Jiang, Y. & Chen, F.*  (2012).  Molasses-based growth and production of oil and astaxanthin by Chlorella zofingiensis. Bioresource Technology, 107, 393-398. 225. Pahl, S.L., Lewis D.M., King, K.D. & Chen, F. (2011). Heterotrophic growth and nutritional aspects of the diatom Cyclotella cryptica (Bacillariophyceae): effect of nitrogen source and concentration. Journal of Appplied Phycology, 24, 301-307.
224. Xu, Y., Ching, Y.P., Zhou, Y., Chiu, J.F., Chen, F.*, & He, Q.Y. (2011). Multiple pathways were involved in Tubeimoside-1-induced cytotoxicity of Hela cells. Journal of Proteomics, 75, 491-501.
223. Peng, X.F., Ma, J.Y., Chen, F. & Wang, M.F. (2011). Naturally occurring inhibitors against the formation of advanced glycation endproducts. Food & Function, 2, 289-301 (new journal, included by ISI).
222. Ma, J.Y., Peng, X.F., Zhang, X.C., Chen, F. & Wang, M.F. (2011). Dual effects of phloretin and phloridzin on the glycation induced by methylglyoxal in model systems. Chemical Research in Toxicology, 24, 1304-1311.
221. Chen, J.N., Jiang, Y., Ma, K.Y., Chen, F. & Chen, Z.Y. (2011).  Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor and HMG-CoA reductase. Journal of Agricultural and Food Chemistry, 59, 6790-6797.
220. Zhu, Q., Sun, Z., Jiang, Y., Chen, F. & Wang, M.F. (2011).  Acrolein scavengers: reactivity, mechanism and impact on health. Molecular Nutrition & Food Research, 55, 1375-1390.
219. Sun, Z., Liu, J., Zeng, X.H., Huangfu, J.Q., Jiang, Y., Wang, M.F. & Chen, F.* (2011). Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells. Food & Function, 2, 251-258.
218. Zhong, Y.J., Huang, J.C., Liu, J., Li, Y., Jiang, Y., Xu, Z.F., Sandmann, G. & Chen, F.* (2011). Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. Journal of Experimental Botany, 62,3659-3669.
217. Wu, Z.Y., Chen, G.Q., Chong, S.K., Mak, N.K., Chen F. & Jiang Y. (2010). Ultraviolet-B radiation improves astaxanthin accumulation in green microalga Haematococcus pluvialis. Biotechnology Letters, 32, 1911-1914.
216. Leung, D.Y.C., Tsui, J.K.Y., Chen, F., Yip, W.K., Vrijmoed L.L.P. & Liu C.H. (2011).  Effects of urban vegetation on urban air quality. Landscape Research, 36, 173-188.
215. Xu, J., Li, M., Mak, N.K., Chen F.& Jiang Y. (2011). Triphenyltin induced oxidative stress and antioxidative responses in the green alga Scenedesmus quadricauda (Chlorophyceae). Ecotoxicology, 20, 73-80.
214. Sun, Z., Liu, J., Zeng, X.H., Huangfu, J.Q., Jiang, Y., Wang, M.F. & Chen, F.* (2011). Astaxanthin is responsible for antiglycoxidative properties of microalga Chlorella zofingiensis. Food Chemistry, 126, 1629-1635.
213. Liu, J., Huang, J.C., Fan, K.W., Jiang, Y. & Chen, F. * (2011). Differential lipid and fatty acid profiles of photoautotrophic and heterotrophic Chlorella zofingiensis: Assessment of algal oils for biodiesel production. Bioresource Technology, 102, 106-110.
212. Liu, J., Fan, K.W., Huang, J.C., Zhong, Y.J., Sun, Z., Jiang, Y. & Chen, F. * (2010). Production potential of Chlorella zofingiensis as a feedstock for biodiesel. Bioresource Technology, 101, 8658-8663.
211. Peng, X.F., Ma, J.Y., Chao, J.F., Chang, R., Li, E., Chen, F.; Wang, M.F. (2010). Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption. Journal of Agricultural and Food Chemistry, 58, 6692-6696.
210. Chen, G.Q., Fan, K.W., Lu, F.P., Li, Q., Aki, T., Chen, F. & Jiang, Y. (2010). Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. New Biotechnology, 27, 382-389.
209. Zeng, X.H., Kong, R., Cheng, K.W., Du, Y.G., Tang, Y.S., Chu, I., Lo, C., Sze, K.H., Chen, F. & Wang, M.F. (2010). Direct trapping of acrylamide as a key mechanism for niacin’s inhibitory activity in carcinogenic acrylamide formation. Chemical Research in Toxicology, 23, 802-807.
208. Liu, J., Zhong, Y.J., Sun, Z., Huang, J.C., Jiang, Y., Sandmann, G. & Chen, F.* (2010). One amino acid substitution in phytoene desaturase makes Chlorella zofingiensis resist to norflurazon and enhance the biosynthesis of astaxanthin. Planta, 232, 61-67.
207. Fan, K.W., Aki, T., Chen, F. & Jiang, Y. (2010). Enhanced production of squalene in the microalga Aurantiochytrium mangrovei by medium optimization and the treatment of terbinafine. World Journal of Microbiology & Biotechnology, 26, 1303-1309.
206. Li, Y.T., Sommerfeld, Chen, F.* & Hu, Q. (2010). Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae). Journal of Applied Phycology, 22, 253-263.
205. Pahl, S.L., Lewis, D.M., Chen, F. & King, K.D. (2010). Heterotrophic growth and nutritional aspects of the diatom Cyclotella cryptica (Bacillariophyceae): Effect of some environmental factors. Journal of Bioscience and Bioengineering, 109, 235-239.
204. Zeng, X.H., Cheng, K.W., Du, Y.G., Kong, R., Lo, C., Chu, I.K., Chen, F. & Wang, M.F. (2010). Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips. Food Chemistry, 121, 424-428.
203. Chen, G.Q., Xiang, W.Z., Lau, C.C., Peng, J., Qiu, J.W., Chen, F. & Jiang, Y. (2010). A comparative analysis of lipid and carotenoid composition of the gonads of Anthocidaris crassispina, Diadema setosum and Salmacis sphaeroides. Food Chemistry, 120, 973-977.
202. Pahl, S.L., Lewis M.D., Chen, F. & King, K.D. (2010). Growth dynamics and the proximate biochemical composition and fatty acid profile of the heterotrophically grown diatom Cyclotella cryptica. Journal of Applied Phycology, 22, 165-171.
201. Law, B.Y.K., Wang, M.F., Ma, D.L., Al-Mousa, F., Michelangeli, F., Cheng, S.H., Ng, M.H.L., To, K.F., Mok, A.Y.F., Ko, R. Y.Y., Lam, S.K.L., Chen, F., Che, C.M., Chiu, P. Ko, B.C.B. (2010). Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Molecular Cancer Therapeutics, 9, 718-730.
200. Sun, Z., Peng, X.F., Fan, K.W., Liu, J., Wang, M.F. & Chen, F.* (2010). Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs). Food Chemistry, 120, 261-267.
199. He, H.Z., Chen, F., Li, H.S., Xiang, W.Z., Li, Y.J. & Jiang, Y. (2010). Effect of iron on growth, biochemical composition and paralytic shellfish poisoning toxins production of Alexandrium tamarense. Harmful Algae, 9, 98-104.
198. Ma, J.Y., Peng, X.F., Cheng, K.W., Kong, R., Chu, I.K., Chen, F. & Wang, M.F. (2010). Effects of melamine on the Maillard reaction between lactose and phenylalanine.  Food Chemistry, 119, 1-6.
197. Huang, G.H., Chen, F.*, Wei, D., Zhang, X.W. & Chen, G. (2010). Biodiesel production by microalgal biotechnology.  Applied Energy, 87, 38-46.
196. Peng, X.F., Ma, J.Y., Cheng, K.W., Jiang, Y., Chen, F. & Wang, M.F. (2010). The effects of grape seed extract fortification on the antioxidant activity and quality attributes of bread. Food Chemistry, 119, 49-53.
195. Cheng, K.W., Wong, C.C., Wang, M., He, Q.Y., Chen, F.* (2010). Identification and characterization of molecular targets of natural products by mass spectrometer. Mass Spectrometry Reviews, 29, 126-155.
194. Zhu, Q., Zheng, Z.P., Cheng, K.W., Wu, J.J., Tang, Y.S., Sze, K.H., Chen, F. & Wang, M.F. (2009). Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal.  Chemical Research in Toxicology, 22, 1721-1727.
193. Tsui, J.K.Y., Guenther, A., Yip, W.K. & Chen, F.* (2009). A biogenic volatile organic compound emission inventory for Hong Kong.  Atmospheric Environment, 43, 6442-6448.
192. Cheng, K.W., Zeng, X.H. Tang, Y.S., Wu, J.J., Liu, Z.W., Sze, K.H., Chu, I.K., Chen, F. & Wang, M.F. (2009). Inhibitory mechanism of naringenin against carcinogenic acrylamide formation and non-enzymatic browning in Maillard model reactions.  Chemical Research in Toxicology, 22, 1483-1489.
191. Fan, K.W., Jiang, Y., Ho, L.T. & Chen, F.* (2009). Differentiation in fatty acid profiles of pigmented and non-pigmented Aurantiochytrium isolated from Hong Kong mangroves. Journal of Agricultural and Food Chemistry, 57, 6334-6341.
190. Huang, G.H., Chen, G. & Chen, F. (2009). Application of Nile red in rapid screening of enhanced lipid production in Chlorella. Biomass & Bioenergy, 33, 1386-1392.
189. Xu, Y., Chiu, J.F., He, Q.Y. & Chen, F.* (2009). Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways. Journal of Proteome Research, 8, 1585-1593.
188. Zeng, X.H., Cheng, K.W., Jiang, Y., Lin, Z.X., Shi, J.J., Ou, S.Y., Chen, F. & Wang, M.F. (2009). Inhibitory of acrylamide formation by vitamins in model reactions and fried potato strips. Food Chemistry, 116, 34-39.
187. Chen, T., Wei, D., Chen, G., Wang, Y. & Chen, F.* (2009). Employment of organic acids to enhance astaxanthin formation in heterotrophic Chlorella zofingiensis. Journal of Food Processing and Preservation, 33, 271-284 (invited paper).
186. Li, H.B., & Chen, F. (2009). Separation and purification of epimedin A, epimedin B, epimedin C and icariin from the medicinal herb Epimedium brevicornum Maxim by dual-mode high-speed counter-current chromatography. Journal of Chromatographic Science, 47, 337-340.
185. Xu, X.R., Li, S.X., Li, X.Y., Gu, J.D., Chen, F., Li, X.Z. & Li, H.B. (2009). Degradation of n-butyl benzyl phthalate using TiO2/UV. Journal of Hazardous Materials, 164, 527-532.
184. Zhu, Q., Liang, C.P., Cheng, K.W., Peng, X.F., Lo, C.Y., Shahidi, F., Chen, F., Ho, C.T. & Wang, M.F. (2009). Trapping effects of green and black tea extracts on peroxidation-derived carbonyl substances of seal blubber oil. Journal of Agricultural and Food Chemistry, 57, 1065-1069.
183. Wei, D., Chen, F., Chen, G., Zhang, X.W., Liu, L.J. & Zhang, H. (2008). Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress. Science in China Series C-Life Sciences, 51, 1088-1093.
182. Peng, J., Xiang, W.Z., Tang, Q.M., Sun, N. Chen, F. & Yuan, J.P. (2008). Comparative analysis of astaxanthin and its esters in the mutant E1 of Haematococcus pluvialis and other green algae by HLPC with a C30 column.  Science in China Series C-Life Sciences, 51, 1108-1115.
181. Li, Y.T., Huang, J.C., Sandmann, G. & Chen, F.* (2008). High-light and sodium chloride stress differently regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (Chlorophyceae). Journal of Phycology, 45, 635-641.
180. Yao, Y., Chen, F., Wang, M.F., Wang, J.S. & Ren, G.X. (2008). Antidiabetic activity of mung bean extracts in diabetic KK-Ay mice. Journal of Agricultural and Food Chemistry, 56, 8869-8873.
179. Yao, Y., Shan, F., Bian, J.S., Chen, F., Wang, M.F. & Ren, G.X. (2008). D-chiro-inositol enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice. Journal of Agricultural and Food Chemistry, 56, 10027-10031.
178. Cheng, K.W., Wong, C.C., Chao, J., Lo, C., Chen, F., Chu, I.K., Che, C., Ho, C.T., Wang, M.F. (2009). Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde. Molecular Nutrition & Food Research, 53, 716-725.
177. Sun, N., Wang, Y., Huang, J.C. & Chen, F.* (2008). Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochemistry, 43, 1288-1292.
176. Cheng, K.W., Wong, C.C., Cho, C.K., Chu, I.K., Sze, K.H., Lo, C., Chen, F. & Wang, M.F. (2008). Trapping of phenylacetaldehyde as a key mechanism responsible for naringenin’s inhibitory activity in mutagenic 2-amino-1-methyl-6-phenylimidazo [4,5-b]phyridine (PhIP) formation. Chemical Research in Toxicology, 21, 2026-2034. (IMARS Highlights, 2009, vol. 4, no. 1, p.17-18.)
175. Li, Y.T., Huang, J.C., Sandmann, G. & Chen, F.* (2008). Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae). Planta, 228, 735-743.
174. Ho, S.Y. & Chen, F.* (2008). Lipid characterization of Mortierella alpina grown at different NaCl concentrations. Journal of Agricultural and Food Chemistry, 56, 7903-7909.
173. Ma, J.Y., Peng, X.F., Cheng, K.W., Chen, B., Chen, F. & Wang, M.F. (2008). Use of capillary electrophoresis to evaluate protective effects of methylglyoxal scavengers on the activity of creatine kinase.  Journal of Separation Science, 31, 2846-2851.
172. Peng, X.F., Ma, J.Y., Cheng, K.W., Chen, B., Chen, F. & Wang, M.F. (2008). High performance liquid chromatographic determination of creatine kinase activity influenced by methylglyoxal. Biomedical Chromatography, 23, 170-174.
171. Hu, Z.Y., Li, Y.T., Sommerfeld, M, Chen, F. & Hu, Q. (2008). Enhanced protection against oxidative stress in an astaxanthin overproduction Haematococcus mutant (Chlorophyceae). European Journal of Phycology, 43, 365-376.
170. Ho, S.Y. & Chen, F.* (2008). Genetic characterization of Mortierella alpina by sequencing the 18S-28S ribosomal gene internal transcribed spacer region. Letters in Applied Microbiology, 47, 250-255.
169. Chen, G.Q., Jiang, Y. & Chen, F.* (2008). Salt-induced alterations in lipid composition of diatom Nitzshia laevis (Bacillariophyceae). Journal of Phycology, 44, 1309-1314.
168. Li, Y.Q., Zhang, X.W., Chen, G., Wei, D. & Chen, F. (2008). Algal lectins for prevention of HIV transmission. Current Medicinal Chemistry, 15, 1096-1104.
167. Wong, C.C., Wang, Y., Cheng, K.W., Chiu, J.F., He, Q.Y. & Chen, F.* (2008). Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells. Journal of Proteome Research, 7, 2050-2058.
166. Peng, X.F., Cheng, K.W., Ma, J.Y., Chen, B., Ho, C.T., Chen, F. & Wang, M.F. (2008). Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. Journal of Agricultural and Food Chemistry 56, 1907-1911.
165. Li, Y.T., Sommerfeld, M., Chen, F.* & Hu, Q. (2008). Consumption of oxygen by astaxanthin biosynthesis: A protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae). Journal of Plant Physiology, 165, 1783-1797.
164. Huang, J.C., Liu, J., Li, Y.T. & Chen, F.* (2008). Isolation and characterization of the phytoene desaturase gene as a potential selective marker for genetic engineering of the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). Journal of Phycology, 44, 684-690.
163. Chen, G.Q., Jiang, Y. & Chen, F.* (2008). Variation of lipid class composition in Nitzschia laevis as a response to growth temperature change. Food Chemistry, 109, 88-94.
162. Zhang, X.W., Yap, Y., Wei, D., Chen, G. & Chen, F. (2008). Novel omics technologies in nutrition research. Biotechnology Advances, 26, 169-176.
161. Peng, X.F., Zheng, Z.P., Cheng, K.W., Shan, F., Ren, G.X., Chen, F., Wang, M.F. (2008). Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts.  Food Chemistry, 106, 475-481.
160. Wong, C.C., Cheng, K.W., He, Q.Y. & Chen, F.* (2008). Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses. Proteomics Clinical Applications, 2, 338-354.
159. Fan, K.W., Fok, L., Lee, J.H.W. & Chen, F.* (2007). Epilithic diatom as a biological indicator for the assessment of water quality in the East River. Water Science & Technology: Water Supply, 7(2), 147-155.
158. Cheng, K.W., Wu, Q., Zheng, Z.P., Peng, X.F., Simon, J.E., Chen, F. & Wang, M.F. (2007). Inhibitory effect of fruit extracts on the formation of heterocyclic amines. Journal of Agricultural and Food Chemistry, 55, 10359-10365.
157. Cheng, K.W., Chen, F. & Wang, M.F. (2007). Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties. Molecular Nutrition & Food Research, 51, 969-976.
156. Zhang, Y.F., Wei, D., Guo, S.Y., Zhang, X.W., Wang, M.F. & Chen, F. (2007). Chemical components and antioxidant activity of the volatile oil from Cassia tora L. seed prepared by supercritical fluid extraction. Journal of Food Lipids, 14, 411-423.
155. Ho, S.Y., Jiang, Y. & Chen, F.* (2007). Polyunsaturated fatty acids (PUFAs) content of fungus Mortierella alpina isolated from soil. Journal of Agricultural and Food Chemistry, 55, 3960-3966.
154. Li, H.B., Wong, C.C., Cheng, K.W. & Chen, F. (2008). Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants. LWT–Food Science and Technology, 41, 385-390.
153. Chen, G.Q., Jiang, Y. & Chen, F.* (2007). Fatty acid and lipid class composition of the eicosapentaenoic acid-producing microalga, Nitzschia laevis. Food Chemistry, 104, 1580-1585.
152. Li, H.B., Jiang, Y., Wong, C.C., Cheng, K.W. & Chen, F.* (2007). Evaluation of two extraction methods for extraction of antioxidants from medicinal plants. Analytical and Bioanalytical Chemistry, 388, 483-488.
151. Fan, K.W., Jiang, Y., Faan, Y.W. & Chen, F.* (2007). Lipid characterization of mangrove thraustochytrid – Schizochytrium mangrovei. Journal of Agricultural and Food Chemistry, 55, 2906-2910.
150. Zhang,X.W., :Li, L., Wei, D., Yap, Y. & Chen, F.* (2007). Moving cancer diagnostics from bench to bedside. Trends in Biotechnology, 25, 166-173.
149. Zhang,X.W., Wei, D., Yap, Y., Li, L., Guo, S.Y. & Chen, F.*(2007). Mass spectrometry-based “omics” technologies in cancer diagnostics. Mass Spectrometry Reviews, 26, 403-431. [Most cited article in the journal in 2007-2008].
148. Li, H.B., Cheng, K.W., Wong, C.C., Fan, K.W. & Chen, F.*, Jiang, Y. (2007). Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae.  Food Chemistry, 102, 771-776.
147. Cheng, K.W., Chen, F. & Wang, M.F. (2006). Heterocyclic amines: chemistry and health. Molecular Nutrition & Food Research. 50, 1150-1170.
146. Hu, J.M., Wei, D., Guo, S.Y. & Chen, F. (2006). Effects of environmental factors and denaturants on the specific absorption spectrum and fluorescence characters of B-phycoerythrin. Spectroscopy and Spectral Analysis, 26, 2258-2263.
145. Shi, X.M., Wu, Z.Y. & Chen, F. (2006). Kinetic modelling of lutein production by heterotrophic Chlorella at various pH and temperatures. Molecular Nutrition & Food Research, 50, 763-768.
144. Chen, G.Q. & Chen, F.* (2006). Growing phototrophic cells without light. Biotechnology Letters, 28, 607-616. [invite review].
143. Huang, J.C., Wang, Y., Sandmann, G., Chen, F.* (2006). Isolation and characterization of a carotenoid oxygenase gene from Chlorella zofingiensis (Chlorophyta). Applied Microbiology and Biotechnology, 71, 473-479.
142. Li, H.B., Fan, K.W. & Chen, F.* (2006). Isolation and purification of canthaxanthin from the microalga Chlorella zofingiensis by high-speed counter-current chromatography. Journal of Separation Science, 29(5), 699-703.
141. Huang, J.C., Chen, F. * & Sandmann G.  (2006). Stress-related differential expression of multiple b-carotene ketolase genes in the unicellular green alga Haematococcus pluvialis.  Journal of Biotechnology, 122, 176-185.
140. Huang, J.C. & Chen, F.* (2006). Simultaneous amplification of 5’ and 3’ cDNA ends based on template-switching effect and inverse PCR.  Biotechniques, 40, 187-189.
139. Wong, C.C., Li, H.B., Cheng, K.W. & Chen, F.* (2006). A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay.  Food Chemistry, 97, 705-711.
138. Wang, S.B., Chen, F.*, Sommerfeld, M. & Hu, Q. (2005). Isolation and characterization of cell wall-deficient Haematococcus pluvialis mutants.  Proteomics, 5, 4839-4851. [featured in the cover of the journal].  
137. Zhang, X.W., Yap, Y.L., Wei, D., Chen, F. & Danchin, A. (2005). Molecular diagnosis of human cancer type by gene expression profiles and independent component analysis. European Journal of Human Genetics, 13, 1303-1311.
136. He, H.Z., Li, H.B., Jiang, Y. & Chen, F. * (2005). Determination of paralytic shellfish poisoning toxins in cultured microalgae by high-performance liquid chromatography with fluorescence detection. Analytical and Bioanalytical Chemistry, 383, 1014-1017.
135. He, H.Z., Li, H.B. & Chen, F. * (2005). Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Analytical and Bioanalytical Chemistry, 383, 875-879.
134. Li, H.B. & Chen, F. * (2005). Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatography. Journal of Chromatography A, 1083, 102-105.
133. Ip, P.F. & Chen, F. * (2005). Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochemistry, 40, 3491-3496.
132. Ip, P.F. & Chen, F. * (2005). Peroxynitrite and nitryl chloride enhance astaxanthin production by the green microalga Chlorella zofingiensis in heterotrophic culture. Process Biochemistry, 40, 3595-3599.
131. Li, H.B. & Chen, F. * (2005). Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography.  Journal of Chromatography A, 1074, 107-110.
130. Chen, F.*, Li, H.B., Wong, R.N.S.,  Ji, B. & Jiang, Y. (2005). Isolation and purification of the bioactive carotenoid zeaxanthin from the microalga Microcystis aeruginosa by high-speed counter-current chromatography.  Journal of Chromatography A, 1064, 183-186.
129. Li, H.B. & Chen, F. * (2005). Simultaneous separation and purification of five coumarins from the Chinese medicinal herb Cnidium monnieri by high-speed counter-current chromatography.  Journal of Separation Science, 28, 268-272.
128. Ip, P.F. & Chen, F.* (2005). Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark.  Process Biochemistry, 40, 733-738.
127. Liu, X.J., Jiang, Y. & Chen, F.* (2005). Fatty acid profile of the edible filamentous cyanobacterium Nostoc flagelliforme at different temperatures and developmental stages in liquid suspension culture.  Process Biochemistry, 40, 371-377.
126. Li, H.B. & Chen, F.* (2004). Preparative isolation and purification of bergapten and imperatorin from the medicinal plant Cnidium monnieri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase. Journal of Chromatography A, 1061, 51-54.
125. Wang, S.B., Chen, F. *, Sommerfeld, M. & Hu, Q. (2004). Proteomic analysis of molecular response to oxidative stress by the green alga Haematococcus pluvialis (Chlorophyceae).  Planta, 220, 17-29.
124. Li, H.B., Jiang, Y. & Chen, F.* (2004). Separation methods used for Scutellaria baicalensis active components.  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 812, 277-290 (invited review for the Annual Review Volume).
123. Lu, H.T., Jiang, Y., Li, H.B., Chen, F. & Wong, M.H. (2004). Simultaneous determination of oxytetracycline, doxycycline, tetracycline and chlortetracycline in tetracycline antibiotics by high-performance liquid chromatography with fluorescence detection.  Chromatographia, 60, 259-264.
122. Li, X.Z., Zhang, D.H., Chen, F., Ma, J., Dong, Y.H. & Zhang, L.H. (2004).  Klebsiella singaporensis sp. nov., a novel isomaltulose-producing bacterium.  International Journal of Systematic and Evolutionary Microbiology 54, 2131-2136.
121. Li, H.B. & Chen, F.* (2004). Preparative isolation and purification of gastrodin from the Chinese medicinal plant Gastrodia elata by high-speed counter-current chromatography. Journal of Chromatography A, 1052(1-2), 229-232.
120. Kumar, D.S.S., Cheung, H.Y., Lau, C.S., Chen, F. & Hyde, K.D. (2004). In vitro studies of endophytic fungi from Tripterygium wilfordii with anti-proliferative activity on human peripheral blood mononuclear cells. Journal of Ethnopharmacology, 94, 295-300.
119. Li, H.B. & Chen, F.* (2004). Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography. Journal of Chromatography A, 1047, 249-253.
118. Lu, H.T., Li, H.B.  Chen, F., Wong M.H. & Jiang, Y. (2004). Determination of triphenyltin and its metabolite diphenyltin by high-performance liquid chromatography with UV detection.  Chromatographia, 60, 113-116.
117. Chen, F., Chan, K.H., Jiang, Y., Kao, R.Y.T., Lu, H.T., Fan, K.W., Cheng, V.C.C., Tsui, W.H.W., Lee, T.S.W., Peiris, J.S.M. & Yuen, K.Y. (2004).  In vitro susceptibility of ten clinical isolates of SARS coronavirus to selected antiviral compounds. Journal of Clinical Virology, 31(1), 69-75. (The most viewed in the journal in 2004).
116. Ip, P.F., Wong, K. H. & Chen, F.* (2004). Enhanced production of astaxanthin by the green microalga Chlorella zofingiensis in mixotrophic culture. Process Biochemistry, 39(11), 1761-1766.
115. Chen, F.*, Lu, H.T. & Jiang, Y. (2004). Purification of paeoniflorin from Paeonia lactiflora Pall. by high-speed counter-current chromatography. Journal of Chromatography A, 1040(2), 205-208.
114. Jiang, Y., Lu, H.T. & Chen, F.* (2004). Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography. Journal of Chromatography A, 1033(1), 183-186.
113. Jiang, Y., Fan, K.W., Wong, R.T.Y. & Chen, F.* (2004). Fatty acid composition and squalene content of the marine microalga Schizochytrium mangrovei.  Journal of Agricultural and Food Chemistry, 52, 1196-1200.
112. Lu, H.T., Jiang, Y. & Chen, F.* (2004). Determination of squalene using high-performance liquid chromatography with diode array detection.  Chromatographia, 59, 367-371.
111. Wang, S.B., Hu, Q., Sommerfeld, M. & Chen, F. * (2004). Cell wall proteomics of the green alga Haematococcus pluvialis (Chlorophyceae).  Proteomics, 4, 692-708.
110. Liang, S.Z., Liu, X.M., Chen, F. & Chen, Z.J. (2004). Current microalgal health food R & D activities in China.  Hydrobiologia, 512, 45-48.
109. Lai, J.P., Jiang, Y., He, X.W., Huang, J.C. & Chen, F.* (2004).  Separation and determination of astaxanthin from microalgal and yeast samples by molecularly imprinted microspheres.  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences , 804(1), 25-30.
108. Lu, H.T., Jiang, Y. & Chen, F.* (2004). Application of preparative high-speed counter-current chromatography for separation of chlorogenic acid from Flos Lonicerae.  Journal of Chomatography A, 1026(1-2), 185-190.
107. Lu, H.T., Jiang, Y. & Chen, F. * (2004). Preparative high-speed counter-current chromatography for purification of shikonin from the Chinese medicinal plant Lithospermum erythrorhizon.  Journal of Chromatography A, 1023(1), 159-163. 
106. Liu, X.J. & Chen, F. * (2003). Cell differentiation and colony alteration of Nostoc flagelliforme, an edible terrestrial cyanobacterium, in different liquid suspension cultures. Folia Microbiologica, 48 (5), 619-626.
105. Wang, S.B., Hu, Q., Sommerfeld, M. & Chen, F.* (2003). An optimized protocol for isolation of soluble proteins from microalgae by two-dimensional gel electrophoresis analysis. Journal of Applied Phycology, 15, 485-496.
104. Lu, H.T., Jiang, Y. & Chen, F. (2003). Application of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensis.  Journal of Chromatography A, 1017,117-123.
103. Lai, J.P., He, X.W. & Chen, F. * (2003). Separation and determination of the antitumor drug piritrexim by molecularly imprinted microspheres in high performance liquid chromatography.  Analytical and Bioanalytical Chemistry, 377(1), 208-213.
102. Liu, X.J., Chen, F.* & Jiang, Y. (2003). Differentiation of Nostoc flagelliforme , and its neighboring species using , fatty acid profiling as a chemotaxonomic tool. Current Microbiology, 47 (6), 467-474.
101. Wen, Z.Y. & Chen, F. * (2003). Heterotrophic production of eicosapentaenoic acid by microalgae.  Biotechnology Advances, 21(4), 273-294. [Invited Article].
100. Li, X.Z., Dong, X.L., Zhao, C.X., Chen, Z. & Chen, F. (2003). Isolation and some properties of cellulose-degrading Vibrio sp. LX-3 with agar-liquefying ability from soil.  World Journal of Microbiology & Biotechnology, 19, 375-379.
99. Lu, H.T., Jiang, Y. & Chen, F. * (2003). Preparative separation and purification of squalene from the microalga Thraustochytrium sp. by high-speed counter-current chromatography.  Journal of Chromatography A, 994, 37-43.
98. Lai, J.P., He, X.W., Jiang, Y. & Chen, F. * (2003). Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid phase extraction. Analytical and Bioanalytical Chemistry, 375, 264-269.
97. Wen, Z.Y. & Chen, F. * (2002). Perfusion culture of the diatom Nitzschia laevis for ultra-high yield production of eicosapentaenoic acid.  Process Biochemistry, 38, 523-529.
96. Zhong, J.J., Pan, Z.W., Wang, Z.Y., Wu, J.Y., Chen, F., Takagi, M. & T. Yoshida (2002). Effect of mixing time on taxoid production in suspension cultures of Taxus chinensis in a centrifugal impeller bioreactor. Journal of Bioscience and Bioengineering, 94 (3), 244-250.
95. Shi, X.M., Jiang, Y. & Chen, F. * (2002).  High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture.  Biotechnology Progress, 18, 723-727.
94. Wen, Z.Y., Jiang, Y. & Chen, F. * (2002).  High cell density culture of the diatom Nitzschia laevis for eicosapentaenoic acid production: fed-batch development. Process Biochemistry, 37, 1447-1453.
93. Li, H.B., Jiang, Y. & Chen, F. * (2002).  Isolation and purification of lutein from the microalga Chlorella vulgaris by extraction after separation.  Journal of Agricultural and Food Chemistry, 50, 1070-1072.
92. Li, H.B., Lai, J.P., Jiang, Y. & Chen, F. * (2002).  Preparative isolation and purification of salvianolic acid B from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography.  Journal of Chromatography A, 943(2), 235-239.
91. Wen, Z.Y. & Chen, F. * (2002). Continuous cultivation of the diatom Nitzschia laevis for eicosapentaenoic acid production: physiological study and process optimization.  Biotechnology Progress, 18, 21-28.
90. Yuan, J.P., Chen, F.*, Liu, X. & Li, X.Z. (2002).  Carotenoid composition in the green microalga Chlorococcum.  Food Chemistry, 76(3), 319-325.
89. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of salidroside from the Chinese medicinal plant Rhodiola sacchalinensis by high-speed counter-current chromatography. Journal of Chromatography A, 932, 91-95.
88. Fan, W.K., Chen, F., Jones E.B.G. & Vrijmoed L.L.P. (2001). Eicosapentaenoic acid and docosahexaenoic acid production and okara uilizing potential of thraustochytrids. Journal of Industrial Microbiology & Biotechnology. 27(4), 199-202.
87. Wen, Z.Y. & Chen, F. * (2001). A perfusion-cell bleeding strategy for enhancing the productivity of eicosapentaenoic acid in the culture of Nitzschia laevis. Applied Microbiology and Biotechnology, 57, 316-322.  
86. Wen, Z.Y. & Chen, F. * (2001). Optimization of nitrogen sources for heterotrophic production of eicosapentaenoic acid by the diatom Nitzschia laevis. Enzyme and Microbial Technology, 29, 341-347.
85. Wen, Z.Y. & Chen, F. * (2001).  Application of statistically-based experimental designs for the optimization of eicosapentaenoic acid production by the diatom Nitzschia laevis.  Biotechnology and Bioengineering, 75 (2), 159-169.
84. Li, H.B. & Chen, F. * (2001). Simultaneous determination of twelve water- and fat-soluble vitamins by high-performance liquid chromatography with diode array detection. Chromatographia, 54, 270-273.
83. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of six diterpenoids from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography.  Journal of Chromatography A, 925, 109-114.
82. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of astaxanthin from the microalga Chlorococcum sp. by high-speed counter-current chromatogaphy.  Journal of Chromatography A, 925, 133-137.
81. Yuan, J.P. & Chen, F.* (2001). Indirect photometric ion chromatographic analysis of anions in Haematococcus pluvialis culture media.  Biotechnology Letters, 23(10), 757-760. (IF: 1.676)
80. Ma, R.Y.N. & Chen, F. * (2001). Enhanced production of free trans-astaxanthin by oxidative stress in the cultures of the green microalga Chlorococcum sp.  Process Biochemistry, 36(12), 1175-1179.
79. Li, H.B., Chen, F. * & Xu, X.R. (2001).  Determination of iodide in seawater and urine by size exclusion chromatography with iodine-starch complex.  Journal of Chromatography A, 918, 335-339.
78. Li, H.B. & Chen, F. * (2001). Simultaneous determination of nine water-soluble vitamins in pharmaceutical preparations by high-performance liquid chromatography with diode array detection. Journal of Separation Science, 24, 271-274.
77. Yuan, J.P. & Chen, F. * (2001).  Kinetics for the reversible isomerization reaction of trans-astaxanthin. Food Chemistry, 73(2), 131-137.
76. Ma, R.Y.N. & Chen, F. * (2001). Induction of astaxanthin formation by reactive oxygen species in mixotrophic culture of Chlorococcum sp. Biotechnology Letters, 23(7), 519-523.
75. Li, H.B., Chen, F. *, Zhang, T.Y., Yang, F.Q. & Xu, G.Q. (2001). Preparative isolation and purification of lutein from the microalga Chlorella vulgaris by high-speed counter-current chromatography.  Journal of Chromatography A, 905, 151-155. 
74. Li, H.B. & Chen, F. * (2000). Determination of viatmin B12 in pharmaceutical preparations by a highly sensitive fluorimetric method. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 368(8), 836-838.
73. Fan, K.W., Chen, F., Jones, E.B.G. & Vrijmoed, L.L.P. (2000). Utilization of food processing waste by Thraustochytrids. Fungal Diversity, 5, 185-194.
72. Wen, Z.Y. & Chen, F. * (2000). Heterotrophic production of eicosapentaenoic acid by the diatom Nitzschia laevis: effects of silicate and glucose. Journal of Industrial Microbiology and Biotechnology, 25, 218-224.
71. Chen, H., Chen, F. *, Chiu, F.C.K. & Lo, C.M.Y. (2001).  The effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of Salvia miltiorrhiza. Enzyme and Microbiology Technology, 28, 100-105.
70. Vonshak, A., Cheung, S.M. & Chen, F. (2000). Mixotrophic growth modifies the response of Spirulina (Arthrospira) platensis (cyanobacteria) cells to light.  Journal of Phycology, 36, 675-679.
69. Li, H.B. &  Chen, F. * (2000). A highly sensitive fluorimetric method for the determination of fluoride in biological material with Al 3+-calcein complex. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 5, 501-504.
68. Li, H.B., Chen, F. * & Xu, X.R. (2000).  A highly sensitive spectrophotometric method with solid phase extraction for the determination of methylmercury in human hair. Journal of Analytical Toxicology, 24(8), 704-707.
67. Li, H.B., Chen, F. * & Jiang, Y. (2000). Determination of vitamin B12 in multivitamin tablets and fermentation medium by high performance liquid chromatography with fluorescence detection, Journal of Chromatography A, 891(2), 243-247.
66. Jiang, Y. & Chen, F. * (2000). Effects of temperature and temperature shift on docosahexaenoic acid production by the marine microalga Crypthecodinium cohnii.  Journal of the American Oil Chemists Society, 77, 613-617.
65. Jiang, Y. & Chen, F. * (2000). Effects of medium glucose concentration and pH on docosahexaenoic acid content of heterotrophic Crypthecodinium cohnii. Process Biochemistry, 35, 1205-1209.
64. Shi, X.M., Zhang, X.W. & Chen, F. * (2000).  Heterotrophic production of biomass and lutein by Chlorella protothecoides on various nitrogen sources.  Enzyme and Microbial Technology, 27, 312-318. 
63. Chen, H. & Chen, F. * (2000). Induction of phytoalexin formation in crown gall and hairy root cultures of Salvia miltiorrhiza by methyl viologen.  Biotechnology Letters, 22(8), 715-720.
62. Wen, Z.Y. & Chen, F. * (2000). Production potential of eicosapentaenoic acid by the diatom Nitzschia laevis.  Biotechnology Letters, 22(9), 727-733.
61. Li, H.B. & Chen, F. * (2000). Determination of silicate in water by ion exclusion chromatograpghy with conductivity detection. Journal of Chromatography A, 874(1), 143-147.
60. Li, H.B., Chen, F. * & Xu, X.R. (2000). Fluorimetric determination of methylmercury as an ion-association complex with rhodamine B in the presence of iodide.  Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 367(5), 499-501.
59. Wen, Z.Y., Teng, X.W. & Chen, F. * (2000). A novel perfusion system for hybridoma cell cultures by two step sequential sedimentation.  Journal of Biotechnology, 79, 1-11.
58. Chen, H. & Chen, F. * (2000). Effects of yeast elicitor on the growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture.  Process Biochemistry, 35, 837-840.
57. Zhang, X.W., Shi, X.M. & Chen, F. * (1999). A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture.  Journal of Industrial Microbiology & Biotechnology, 23(6), 503-507. 
56. Chen, H. & Chen, F. * (2000). Effect of yeast elicitor on the secondary metabolism of Ti transformed Salvia miltiorrhiza cell suspension cultures.  Plant Cell Reports, 19(7), 710-717.
55. Zhong, J.J., Chen, F. & Hu, W.W. (2000). High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin.  Process Biochemistry, 35, 491-496.
54. Yuan, J.P. & Chen, F. * (2000). Purification of trans-astaxanthin from a high-yielding astaxanthin ester-producing strain of the microalga Haematococcus pluvialis.  Food Chemistry, 68, 443-448.
53. Jiang, Y. & Chen, F. * (1999). Effects of salinity on cell growth and docosahexaenoic acid content of the heterotrophic marine microalga Crypthecodinium cohnii.  Journal of Industrial Microbiology & Biotechnology, 23(6), 508-513.
52. Ren, G. & Chen, F. * (2000). Drying of steamed Asian ginseng (Panax ginseng) roots by microwave-hot air combination.  Pharmazie, 55(2), 124-128. 
51. Ren, G., Zhang, X.W. & Chen, F. * (2000). Predicting colour kinetics during red Asian ginseng (Panax ginseng) preparation. Pharmazie, 55(4), 300-302. 
50. Chen, Q., Chen, F. & Li, Z.Y. (1999).  Preparation and surfactant properties of amino acid based surfactants.  Chinese Chemical Letters, 10(9), 789-792.
49. Zhang X.W., Chen, F. * & Johns, M.R. (1999). Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures. Process Biochemistry, 35, 385-389.
48. Yuan, J.P. & Chen, F. * (1999). Isomerization of trans-astaxanthin in organic solvents. Journal of Agricultural & Food Chemistry, 47, 3656-3660. 
47. Zhang, X.W., Gong, X.D. & Chen, F. * (1999). Dynamics and stability analysis of the growth and astaxanthin production system of Haematococcus pluvialis.  Journal of Industrial Microbiology & Biotechnology, 23(2), 133-137.
46. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of rosmarinic acid and lithospermic acid B in Ti transformed Salvia miltiorrhiza cell suspension cultures.  Process Biochemistry, 34, 777-784.
45. Jiang, Y., Chen, F. * & Liang, S.Z. (1999). Production potential of docosahexaenoic acid by the heterotrophic marine dinoflagellate Crypthecodinium cohnii.  Process Biochemistry, 34, 633-637.
44. Chen, H. & Chen, F. * (1999). Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures.  Biotechnology Letters, 21(9), 803-807.
43. Zhang, Y.M. & Chen, F. * (1999). A simple method for efficient separation and purification of c-phycocyanin and allophycocyanin from Spirulina platensis. Biotechnology Techniques (changed to Biotechnology Letters), 13(9), 601-603.
42. Chen, H. & Chen, F. * (1999).  Kinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension cultures.  Biotechnology Letters, 21(8), 701-705.
41. Zhang, X.W., Gong, X.D. & Chen, F.*  (1999). Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. Journal of Industrial Microbiology Biotechnology, 23, 691-696. 
40. Boussiba, S., Wang, B., Yuan, J.P., Zarka. A. & Chen, F.* (1999). Changes in pigment profile in the green alga Haematococcus pluvialis exposed to environmental stresses.  Biotechnology Letters, 21, 601-604.
39. Zhang, X.W., Zhang, Y.M. & Chen, F.*  (1999). Application of mathematical models to the determination optimal glucose concentration and light intensity for mixotrophic culture of Spirulina platensis.  Process Biochemistry, 34(5), 477-481. 
38. Shi, X.M., Liu, H.J., Zhang, X.W. & Chen, F.* (1999). Production of biomass and lutein by Chlorella protothecoides at various glucose concentrations in heterotrophic cultures. Process Biochemistry, 34(4), 341-347.
37. Ren, G. & Chen, F. * (1999). Simultaneous quantification of ginsenosides in American ginseng (Panax quinquefolium) root powder by visible/near infrared reflectance spectroscopy.  Journal of Agricultual & Food Chemistry, 47, 2771-2775.
36. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of lithospermic acid B and rosmarinic acid in hairy root cultures of Salvia miltiorrhiza.  Journal of Industrial Microbiology & Biotechnology, 22, 133-138.
35. Ren, G. & Chen, F. * (1999). Degradation of ginsenosides in American ginseng (Panax quiquefolium) extracts during microwave and conventional heating.  Journal of Agricultural & Food Chemistry, 47(4), 1501-1505.
34. Shi, X.M. & Chen, F. * (1999). Production and rapid extraction of lutein and the other lipid-soluable pigments from Chlorella protothecoides grown under heterotrophic and mixotrophic conditions.  Nahrung/Food (changed to Molecular Nutrition and Food Research), 43(2), 109-113.
33. Yuan, J.P. & Chen, F. * (1999).  Simultaneous separation and determination of sugars, ascorbic acid and furanic compounds by HPLC-dual detection.  Food Chemistry, 64(3), 423-427.
32. Yuan, J.P. & Chen, F. * (1999). Hydrolysis kinetics of astaxanthin esters and stability of astaxanthin of Haematococcus pluvialis during saponification. Journal of Agricultural & Food Chemistry, 47(1), 31-35.
31. Zhang, X.W., Zhang, Y.M. & Chen, F.* (1998). Kinetic models for phycocyanin production by high cell density mixotrophic culture of the microalga Spirulina platensis.  Journal of Industrial Microbiology & Biotechnology, 21(6), 283-388.
30. Yuan, J.P. & Chen, F. * (1998). Degradation of ascorbic acid in aqueous solution.  Journal of Agricultural & Food Chemistry, 46(12), 5078-5082.
29. Vazhappilly, R. & Chen, F. * (1998). Heterotrophic production potential of omega-3 polyunsaturated fatty acids by microalgae and algae-like microorganisms.  Botanica Marina, 41, 553-558.
28. Yuan, J.P. & Chen, F. * (1998).  Chromatographic separation and purification of trans-astaxanthin from the extracts of Haematococcus pluvialis.  Journal of Agricultural & Food Chemistry, 46(8), 3371-3375.
27. Li, X., Lin, W., Gao, P. & Chen, F.  (1998). Endoglucanase S, a novel endocellulase exhibiting exoglucanase activity from a newly isolated Streptomyces sp. LX. Journal of Applied Microbiology, 85, 347-356.
26. Yuan, J.P., Chen, H. & Chen, F. * (1998). Simultaneous determination of rosmarinic acid, lithospermic acid B and related phenolics in Salvia miltiorrhiza by HPLC.  Journal of Agricultural & Food Chemistry, 46(7), 2651-2654.
25. Li, X. & Chen, F. * (1998). Improvement in isolation of gliding bacteria by the elimination of soluable sugars.  Biotechnology Techniques (changed to Biotechnology Letters), 12(5), 343-345.
24. Ren, G. & Chen, F. * (1998). Drying of American ginseng (Panax quinquefolium) roots by microwave-hot air combination.  Journal of Food Engineering, 35(4), 433-443.
23. Gong, X. & Chen, F. * (1998). Influence of medium components on astaxanthin content and production of Haematococcus pluvialis.  Process Biochemistry, 33(4), 385-391.
22. Yuan, J.P. & Chen, F. * (1998). Separation and identification of furanic compounds in fruit juices and drinks by HPLC-PDA detection.  Journal of Agricultural & Food Chemistry, 46, 1286-1291.
21. Vazhappilly, R. & Chen, F. * (1998). Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their heterotrophic growth.  Journal of the American Oil Chemists Society, 75, 393-397.
20. Chen, H., Yuan, J.P., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1997). Tanshinone production in Ti transformed Salvia miltiorrhiza cell suspension cultures.  Journal of Biotechnology, 58(3), 147-156.
19. Chen, F. *, Chen, H. & Gong, X. (1997). Mixotrophic and heterotrophic growth of Haematococcus lacustris and rheological behaviour of the cell suspensions.  Bioresource Technology, 62(1-2), 19-24.
18. Gong, X.D. & Chen, F. * (1997).  Optimization of culture medium for growth of Haematococcus pluvialis.  Journal of Applied Phycology, 9(5), 437-444.
17.  Shi, X.M., Chen, F. *, Yuan, J.P. & Chen, H. (1997).  Heterotrophic production of lutein by selected Chlorella strains.  Journal of Applied Phycology, 9(5), 445-450.
16. Ren, G., Chen, F. *, Lian, H., Zhao, J. and Gao, X. (1997). Changes in hormone contents of Panax quinquefolium seeds during stratification. Journal of Horticultural Science (changed to Journal of Horticultural Science & Biotechnology) , 72(6), 901-906.
15. Gong, X.D. & Chen, F. * (1997). Rapid detection of heterotrophic growth of Haematococcus pluvialis using indirect conductimetry.  Biotechnology Techniques (changed to Biotechnology Letters), 11(11), 841-844. 
14. Ren, G. and Chen, F. * (1997).  Determination of moisture content of ginseng by near infra-red reflectance spectroscopy.  Food Chemistry, 60, 433-436.
13. Yuan, J.P. & Chen, F. * (1997). Identification of astaxanthin isomers in Haematococcus lacustris by HPLC-photodiode array detection.  Biotechnology Techniques (changed to Biotechnology Letters), 11(7), 455-459. 
12. Yuan, J.P., Gong, X.D. & Chen, F. * (1997).  Separation and analysis of carotenoids and chlorophylls in Haematococcus lacustris by high-performance liquid chromatography photodiode array detection.  Journal of Agricultural & Food Chemistry, 45(5), 1952-1956.
11. Chen, F. * & Zhang, Y. (1997).  High cell density mixotrophic culture of Spirulina platensis on glucose for phycocyanin production using a fed-batch system.  Enzyme and Microbial Technology, 20, 221-224. (
10. Shi, X.M. and Chen, F. * (1997). Stability of lutein under various storage conditions.  Nahrung/Food (changed to Molecular Nutrition and Food Research), 41(1), 38-41.
9. Chen, F.* (1996).  High cell density culture of microalgae in heterotrophic growth.  Trends in Biotechnology, 14(11), 421-426 [featured in the cover of the journal; the article was also cited by a landmark article in Science (292: 2073-2075, 2001) as one of the major reasons they initiated the study].
8. Chen, F. *, Zhang, Y. & Guo, S. (1996).  Growth and phycocyanin formation of Spirulina platensis in photoheterotrophic culture.  Biotechnology Letters, 18(5), 603-608. 
7. Chen, F. * & Johns, M.R. (1996). Heterotrophic growth of Chlamydomonas reinhardtii on acetate in chemostat culture.  Process Biochemistry, 31(6), 601-604.
6. Chen, F. & Johns, M.R. (1996).  High cell density culture of Chlamydomonas reinhardtii on acetate using fed-batch and hollow-fibre cell-recycle systems.  Bioresource Technology, 55(2), 103-110.
5. Chen, F. * & Johns, M.R. (1996). Relationship between substrate inhibition and maintenance energy of Chlamydomonas reinhardtii in heterotrophic culture.  Journal of Applied Phycology, 8(1), 15-19.
4. Yuan, J.P., Gong X.-D. & Chen, F. * (1996). Separation and identification of astaxanthin esters and chlorophylls in Haematococcus lacustris by HPLC.  Biotechnology Techniques (changed to Biotechnology Letters), 10(9), 655-660.
3. Chen, F. *& Johns, M.R. (1995).  A strategy for high cell density culture of heterotrophic microalgae with inhibitory substrates.  Journal of Applied Phycology, 7, 43-46.
2. Chen, F. * & Johns, M.R. (1994).  Substrate inhibition of Chlamydomonas reinhardtii by acetate in heterotrophic culture.  Process Biochemistry, 29, 245-252.
1. Chen, F.* & Johns, M.R. (1991).  Effect of C/N ratio and aeration on the fatty acid composition of heterotrophic Chlorella sorokiniana.  Journal of Applied Phycology, 3, 203-209.