霍云龙

博士、特聘研究员


北京大学工学院力学与工程科学系 特聘研究员


联系电话:010-62755417
电子邮箱:yhuo@pku.edu.cn


霍云龙

个人简介:

霍云龙,北京大学工学院力学与工程科学系研究员、博士生导师、青年千人计划获得者。在北京大学工学院创建“心血管力学与介入心脏病学实验室”。现任《Am J Physiol-Heart C》编委。被邀为30多个国际学术杂志审稿。长期从事心血管生物力学、无创诊断方法和介入医疗器械的研究工作;在血液动力学、血管壁软组织力学、三维冠状血管网络、高血压和心室肥大、心衰、冠状动脉狭窄、无创诊断冠脉血流储备分数、弥漫性冠状动脉疾病等方面取得了一些有重要意义的研究成果;在国际一流期刊(例如:Circ Res、Radiology、Biomaterials、J R Soc Interface、J Hypertens、Biophys J、Am J Physiol-Heart C)发表学术论文60多篇,他引800多次。

 

教育背景:

· 学士:清华大学,水利水电工程系,1999
· 硕士:新加坡国立大学,机械工程系,2001
· 博士:华盛顿州立大学,机械工程系,2005

 

工作经历:

博士后:加州大学尔湾分校,生物医学工程系,2006/06

助理研究教授:印第安纳大学与普渡大学印第安纳波里斯联合分校,生物医学工程系,2012/12

研究员:北京大学,力学与工程科学系,2013年1月1日-至今

 
实验室建设:

 
研理论与数值方法发展(干实验室建设):

 
 
研究领域:

心血管生物力学
无创诊断方法
医疗器械研发

 

主要科研项目:

  1. 主持国家自然科学基金面上项目(11672006)(86万人民币),“超细颗粒PM0.1加速心衰发展的生物力学研究”,2017.01-2020.12,PI
  2. 主持第十期中新联合研究计划(2014DFG32740)(中方:75万人民币;新方:30万新元),“肥胖并发症-心血管疾病的诊断和预防”,2014.04-2017.03,PI
  3. 主持国家自然科学基金面上项目(11372010)(86万人民币),“冠心病心衰引起的冠状血管网络结构和功能重塑研究”,2014.01-2017.12,PI
  4. 主持北京大学仪器创新基金(20万人民币),“研发多通道三维肌动描记器”,2014.10-2016.04,PI
  5. 主持“国家青年千人”基金(300万人民币),2013-2016,PI
  6. 主持美国心脏协会科学家发展基金项目(30.8万美元),“急性狭窄的冠脉流量分析”,2008-2012,PI
  7. 参与美国国家卫生研究院R01基金项目(180万美元),“基于CT扫描,诊断弥漫性冠状动脉病变”,2009-2013,Co-Investigator (PI, Ghassan S. Kassab)
  8. 参与美国国家卫生研究院R01基金项目(110万美元),“用冠状动脉旁路移植术和心室恢复手术来治疗心脏衰竭”,2009-2011,Co-Investigator (PI, Julius M. Guccione)

 

SCI期刊论文:

Website at Google Scholar: http://scholar.google.com/citations?user=ogefOREAAAAJ&hl=en

2016年

  1. H. Wu, G. S. Kassab, W. Tan* and Y. Huo*, Flow velocity is relatively uniform in the coronary sinusal venous tree: structure-function relation, Journal of Applied Physiology, In press, https://www.ncbi.nlm.nih.gov/pubmed/27789767
  2. Y. Gong, Y. Feng, X. Chen, W. Tan, Y. Huo* and G. S. Kassab, Intraspecific scaling laws are preserved in mild ventricular hypertrophy, but not in congestive heart failure, American Journal of Physiology - Heart and Circulatory Physiology, 311:H1108-17, 2016
  3. X. Chen, Y. Gao, T. Fan, B. Lu, X. Jia, L. Zhong, G. S. Kassab, W. Tan* and Y. Huo*, Hemodynamics in coronary arterial tree of serial stenoses, PLoS ONE, 11: e0163715, 2016
  4. Y. Huo* and G. S. Kassab*, Scaling laws of coronary circulation in health and disease, Journal of Biomechanics, 49:2531-2539, 2016
  5. X. Yin, X. Huang, Y. Feng, W. Tan, H. Liu* and Y. Huo*, Interplay of proximal flow confluence and distal flow divergence in patient-specific vertebrobasilar system, PLoS ONE, 11:e0159836, 2016
  6. T. Fan, Y. Lu, Y. Gao, J. Meng, W. Tan, Y. Huo* and G. S. Kassab*, Hemodynamics of left internal mammary artery bypass graft: effect of anastomotic geometry, coronary artery stenosis, and postoperative time, Journal of Biomechanics, 49:645–652, 2016
  7. X. Huang, X. Yin, Y. Xu, X. Jia, J. Li, P. Niu, W. Shen, G. S. Kassab, W. Tan and Y. Huo*, Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations, American Journal of Physiology - Heart and Circulatory Physiology, 310:H639-47, 2016
  8. J. M. Zhang, L. Zhong, T. Luo, A. M. Lomarda, Y. Huo, J. Yap, et al. Simplified models of non-invasive fractional flow reserve based on CT images, PLoS ONE, 11:e0153070, 2016

2015

  1. X. Chen, P. Niu, X. Niu, W. Shen, F. Duan, L. Ding, X. Wei, Y. Gong, Y. Huo, G. S. Kassab, W. Tan* and Y. Huo*, Growth, ageing and scaling laws of coronary arterial trees, Journal of the Royal Society Interface, 12:20150830, 2015
  2. Y. Huo and G. S. Kassab, Remodeling of left circumflex coronary arterial tree in pacing-induced heart failure, Journal of Applied Physiology, 119(4):404-411, 2015
  3. J. M. Zhang, T. Luo, S. Y. Tan, A.M. Lomarda, A.S. Wong, F. Y. Keng, J. C. Allen, Y. Huo, B. Su, X. Zhao, M. Wan, G. S. Kassab, R. S. Tan, L. Zhong, Hemodynamic analysis of patient-specific coronary artery tree. International Journal for Numerical Methods in Biomedical Engineering. 31: e02708, 2015
  4. J. S. Choy, T. Luo, Y. Huo, T. Wischgoll, K. Schultz, S. D. Teague, M. Sturek, G. S. Kassab, Compensatory enlargement of Ossabaw miniature swine coronary arteries in diffuse atherosclerosis. IJC Heart & Vasculature. 6:4-11, 2015

2014年

  1. X. Chen, W. Tan, G. S. Kassab, Y. Huo*, Governing equations and respective numerical methods in cardiovascular hemodynamics, Experimental & Clinical Cardiology, 20:5418,2014
  2. J. M. Zhang, L. Zhong, T. Luo, Y. Huo, S. Y. Tan, A. S. Wong, B. Su, M. Wan, X. Zhao, G. S. Kassab, H. P. Lee, B. C. Khoo, C. W. Kang, T. Ba, R. S. Tan, Numerical simulation and clinical implications of stenosis in coronary blood flow. BioMed Research International, 2014:514729,2014
  3. B. Su, Y. Huo, G. S. Kassab, F. Kabinejadiand, S. Kimd, H. L. Leod, L. Zhong, Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenosis, Computers in Biology and Medicine, 47C:130-138, 2014
  4. T. Luo, T. Wischgoll, B. K. Koo, Y. Huo, G. S. Kassab, IVUS Validation of Patient Coronary Artery Lumen Area obtained from CT Images, PLoS ONE, 9: e86949, 2014

2013年

  1. X. Chen, L. Guo, J. Kang, Y. Huo, S. Wang, W. Tan, Calcium waves initiating from the anomalous subdiffusive calcium sparks, Journal of the Royal Society Interface, 11(91):20130934, 2013
  2. Y. Huo, T. Luo, J. M. Guccione, S. D. Teague, W. Tan, J. A. Navia and G. S. Kassab, Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis, PLoS ONE, 8:e73769, 2013
  3. Y. Huo, T. Wischgoll, S. Choy, S. Sola, J. L. Navia, S. D. Teague, D. L. Bhatt, and G. S. Kassab, CT-based diagnosis of diffuse coronary artery disease on the basis of scaling power laws, Radiology, 268:694-701, 2013
  4. H. Chen, Y. Huo and G. S. Kassab, Biaxial Constitutive Model of Active Coronary Media Based on Microstructural Information, Engineering, 5:341-346, 2013
  5. H. Chen, T. Luo, X. Zhao, X. Lu, Y. Huo, and G. S. Kassab, Microstructural constitutive model of active coronary media, Biomaterials, 34:7575-83, 2013
  6. Y. Huo, S. Choy, T. Wischgoll, T. Luo, S. D. Teague, D. L. Bhatt, and G. S. Kassab, Computed tomography-based diagnosis of diffuse compensatory enlargement of coronary arteries using scaling power laws, Journal of the Royal Society Interface, 10:20121015, 2013
  7. Y. Huo, X. Zhao, Y. Cheng, X. Lu, and G. S. Kassab, Two-layer model of coronary artery vasoactivity, Journal of Applied Physiology, 114:1451-1459, 2013

2004-2012

  1. Y. Huo, M. Svendsen, J. S. Choy, Z. D. Zhang, and G. S. Kassab, A validated predictive model of coronary fractional flow reserve, Journal of the Royal Society Interface, 9: 1325-1338, 2012
  2. Y. Huo and G. S. Kassab, Intraspecific scaling laws of vascular trees, Journal of the Royal Society Interface, 9: 190-200, 2012
  3. Y. Huo and G. S. Kassab, Compensatory remodeling of coronary microvasculature maintains shear stress in porcine left-ventricular hypertrophy, Journal of Hypertension, 30: 608-616, 2012
  4. Y. Huo, Y. Cheng, X. Zhao, X. Lu, and G. S. Kassab, Biaxial activity of porcine coronary artery, American Journal of Physiology - Heart and Circulatory Physiology, 302: H2058-2063, 2012
  5. Y. Huo, G. Finet, T. Lefevre, Y. Louvard, I. Moussa, and G. S. Kassab, Optimal diameter of diseased bifurcation segment: a practical rule for percutaneous coronary intervention, EuroIntervention, 7: 1310-1316, 2012
  6. Y. Huo, G. Finet, T. Lefevre, Y. Louvard, I. Moussa, and G. S. Kassab, Which diameter and angle rule provides optimal flow patterns in a coronary bifurcation? Journal of Biomechanics, 45: 1273-1279, 2012
  7. H. W. Choi, N. D. Farren, Z. D. Zhang, Y. Huo, and G. S. Kassab, Conductance catheter measurements of lumen area of stenotic coronary arteries: theory and experiment, Journal of Applied Physiology, 111: 758-65, 2011
  8. Z. D. Zhang, M. Svendsen, J. S. Choy, A. K. Sinha, Y. Huo, K. Yoshida, S. Molloi and  G. S. Kassab, New Method to Measure Coronary Velocity and Coronary Flow Reserve, American Journal of Physiology - Heart and Circulatory Physiology, 301: H21-H28, 2011
  9. G. Finet, Y. Huo, G. Rioufol, J. Ohayon, P. Guerin, and G. S. Kassab, Structure-function relation in the coronary artery tree: From fluid dynamics to arterial bifurcations, EuroIntervention, 6: J10-J15, 2010
  10. H. Zheng*, Y. Huo*, M. Svendsen, and G. S. Kassab, Effect of blood pressure on vascular hemodynamics in acute tachycardia, Journal of Applied Physiology, 109: 1619-1627, 2010 (*H. Zheng and Y. Huo contributed equally to this study)
  11. Y. Huo and G. S. Kassab, Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree, Journal of Applied Physiology, 107: 500-505, 2009
  12. Y. Huo, B. Kaimovitz, Y. Lanir, T. Wischgoll, J. I. E. Hoffman, and G. S. Kassab, Biophysical model of the spatial heterogeneity of myocardial flow, Biophysical Journal, 96: 4035-4043, 2009
  13. Y. Huo, J. S. Choy, M. Svendsen, A. K. Sinha, and G. S. Kassab, Effects of vessel compliance on flow pattern in porcine epicardial right coronary arterial tree, Journal of Biomechanics, 42: 594-602, 2009
  14. Y. Huo and G. S. Kassab, A scaling law of vascular volume, Biophysical Journal, 96: 347-353, 2009
  15. Y. Huo and G. S. Kassab, The scaling of blood flow resistance: from a single vessel to the entire distal tree, Biophysical Journal, 96: 339-346, 2009
  16. G. S. Kassab, J. S. Choy, M. Svendsen, A. K. Sinha, M. Alloosh, M. Sturek, Y. Huo, G. E. Sandusky, J. Hermiller, A novel system for the reconstruction of a coronary artery lumen profile in real time: a preclinical validation, American Journal of Physiology - Heart and Circulatory Physiology, 297: H485-492, 2009
  17. Y. Huo, X. Guo, and G. S. Kassab, The flow field along the entire length of mouse aorta and primary branches, Annals of Biomedical Engineering, 36: 685-699, 2008
  18. B. Kaimovitz*, Y. Huo*, Y. Lanir, and G. S. Kassab, Diameter asymmetry of porcine coronary arterial trees: structural and functional implications, American Journal of Physiology - Heart and Circulatory Physiology, 294: H714-H723, 2008 (*B. Kaimovitz and Y. Huo contributed equally to this study)
  19. Z. Liu, Y. Huo, J. A. Navia, and G. S. Kassab, A magnetic device to eliminate endograft migration: theory and experiment, Annals of Biomedical Engineering, 36:57-65, 2008
  20. Y. Huo, C. Linares, and G. S. Kassab, Capillary perfusion and wall shear stress are restored in the coronary circulation of hypertrophic right ventricle, Circulation Research, 100: 273-283, 2007
  21. Y. Huo, T. Wischgoll, and G. S. Kassab, Flow patterns in three-dimensional porcine epicardial coronary arterial tree, American Journal of Physiology - Heart and Circulatory Physiology, 293: H2959-H2970, 2007
  22. Y. Huo and G. S. Kassab, A hybrid one-dimensional/Womersley model of pulsatile blood flow in the entire coronary arterial tree, American Journal of Physiology - Heart and Circulatory Physiology, 292: H2623-H2633, 2007
  23. G.S. Kassab, Y. Huo, and G. Buckberg, Perfusion dynamics and clinically-relevant models of coronary flow distribution, Reply to the Editor, Journal of Thoracic and Cardiovascular Surgery, 133: 1396-1396, 2007
  24. Y. Huo and G. S. Kassab, Pulsatile blood flow in the entire coronary arterial tree: theory and experiment, American Journal of Physiology - Heart and Circulatory Physiology, 291: H1074-H1087, 2006
  25. Y. Huo* and B.Q. Li, Surface deformation and convection in electrostatically-positioned droplets of immiscible liquids under microgravity, ASME J. Heat Trans., 128: 520-529, 2006
  26. Y. Huo and B.Q. Li, Boundary/finite element modeling of three-dimensional electromagnetic heating during microwave food processing, ASME J. Heat trans., 127: 1159-1166, 2005
  27. Y. Huo and B. Q. Li, A mathematical model for Marangoni flow and mass transfer in electrostatically positioned droplets, Metallurgical and Materials Transactions B, 36B: 271-281, 2005
  28. Y. Huo and B. Q. Li, Three-dimensional Marangoni convection in electrostatically positioned droplets under microgravity, Int. J. Heat Mass Trans., 47: 3533-3547, 2004
  29. Y. Huo, S. P. Song and B. Q. Li, Droplet deformation and 2-D/3-D Marangoni flow phenomena in droplets levitated by electric fields, Materials and Manufacturing Processes. 19: 761-775, 2004
  30. R. Akarapu, B. Q. Li, Y. Huo, J. Tang, and Frank Liu, Integrated modeling of microwave food processing and comparison with experimental measurements, J Microw Power Electromagn Energy, 39: 153-165, 2004
  31. T. S. Lee, Z. Xu, and Y. Huo, Computer visualization of fluid circulation in annuli of heated rotating cylinders of low Prandtl number fluids, International Journal of Computational Engineering Science, 5: 357-378, 2004

Journal Papers in Revise or in Review (* refers to the corresponding author)

  1. T. Fan, Y. Lu, D. Luo, F. Feng, W. Tan* and Y. Huo*, A comparison of postoperative morphometric and hemodynamic changes between saphenous vein and left internal mammary artery grafts, In review
  2. Y. Feng, X. Yin, X. Huang, F. Feng, W. Zhang, W. Tan* and Y. Huo*, Morphometric and hemodynamic analysis of human stenotic vertebrobasilar system, In review
  3. H. Wu, L. Li, P. Niu, X. Huang, X. Niu, J. Zhu, W. Shen, W. Tan, Y. Wu* and Y. Huo*, The structure-function remodeling in rabbit hearts of myocardial infarction, In review


专著章节

  1. F. Kabinejadian, Y. Huo, D. Ghista,  and G. Kassab, Coronary Circulation Blood Flow Analysis and Coronary Bypass Graft Flow and Design, DN Ghista eds., Cardiology Science and Technology, CRC Press (Taylor & Francis Group), 2016
  2. B. Kaimovitz, Y. Huo, Y. Lanir, and G. S. Kassab, Structure-Function Relation of Coronary Vasculature, GS Kassab, and M. Sacks, eds., Structure-Based Mechanics of Tissues and Organs, Springer, 2016
  3. Y. Huo* and G. S. Kassab, Governing equations of blood flow and respective numerical methods, In Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure, edited by Julius M. Guccione, G S. Kassab, and M, Ratcliffe, Springer, 2010
  4. H. Y. Chen, L. Zhu, Y. Huo, Y. Liu, and G. S. Kassab, Fluid-structure interaction modeling in the cardiovascular system, In Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure, edited by Julius M. Guccione, G. S. Kassab, and M, Ratcliffe, Springer, 2010
  5. Z. Xu, Y. Huo, and T. S. Lee, Computer visualization of fluid circulation in annuli of heated rotating cylinders of low Prandtl number fluids, pp 108, In Recent Advances in Computational Science and Engineering, edited by H. P. Lee and K Kumar, 2002