报告人: 邱明峰，新西兰坎特伯雷大学

时  间：2月29日（周四）16:00—17：00

地  点：北京大学工学院力学楼434

主持人：谢金翰 助理教授

内容简介：

We study the mechanics of epithelial tissues, a fundamental type of cellular tissues of animals. Traditionally it is believed that genes and biochemistry instruct mechanical events. Recently, it is becoming clear that mechanics also feeds back onto and drives gene expression and biochemical signalling, but how mechanical feedback affects tissue behaviour remains poorly understood. One commonly used modelling approach, namely the vertex model, describes an epithelial monolayer as a network of active edges representing cell-cell boundaries. These edges actively produce and sustain tension, which is thus transmitted throughout the tissue. Inspired by experimental observations, we propose a dynamical vertex model combining passive edge viscoelasticity and active molecular motor recruitment. The model incorporates a known feedback loop in which edge tension regulates motor activities. Studying the emergent response of this type of tissue to external forces using both theory and computations, we show that in the presence of feedback, a tissue can become patterned with supracellular cables consisting of chains of strongly contracting edges. Our theory provides a potential explanation for the formation and refinement of these cables, which are ubiquitous in the development of organisms. From a physical point of view, the spontaneous contractile paths offer mechanisms for long-range force transmission, highlighting novel self-organized mechanical states in living matter.

报告人简介：

邱明峰，本科就读于北京大学工学院力学系，曾在美国犹他大学、加拿大英属哥伦比亚大学、法国巴黎高等师范学校学习和从事研究工作，现为新西兰坎特伯雷大学讲师。主要研究方向为软物质物理，包括非牛顿流体、界面流动现象，以及生物组织力学。

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